Investigation of natural products from medicinal plants or microorganisms, and synthesis of enzyme inhibitors

We have been investigating the structures of antibiotics and other secondary metabolites from microorganisms for many years. In addition, we are interested in the constituents of plants, which are used in traditional medicine (e.g. in Tanzania or Mozambique). Inspired by these natural products, we synthesize model compounds to compare their spectral and chemical properties with those of the natural products. In those cases where we can isolate only minute amounts of the substances from the natural sources, we proceed to the total synthesis of these substances. Thus we get larger samples to fully investigate the chemical and biological properties of these compounds.

Some of these natural products or of the analogs synthesized proved to be biologically interesting. They showed activity against Plasmodium falciparum (malaria) or proved to interfere with the quorum sensing system of Chromobacterium violaceum.

Furthermore, we synthesized a number of slective and potent inhibitors of tyrosine kinases, which have IC50 values in the low nanomolar range.

NO open positions:

There are currently NO OPEN POSITIONS for Ph.D students, postdoctoral fellows or summer trainees in my group.


updated 19.1.2005 Sé.