Prof. Dr. Dennis G. Gillingham

Principal Investigator

Career

Full CV is available here

Bibliography

2018

  • Stefanie Geigle, Dnyaneshwar Rasale and Dennis G. Gillingham, «Synthesis of Various Water Soluble and Stable Copper Complexes Bearing N‐Heterocyclic Carbene Ligands and Their Activity in DNA Alkylation», Helvetica Chimica Acta 2018, 101, e1800183. doi:10.1002/hlca.201800183.

  • Dennis G. Gillingham and Dnyaneshwar Rasale, «Direct and Selective Modification of RNA – An Open Challenge in Nucleic Acid Chemistry», Chimia 2018, 72, 11, 777─781. doi:10.2533/chimia.2018.777.

  • Dnyaneshwar Rasale, Kiran Patil, Basilius Sauter, Stefanie Geigle, Saule Zhanybekova and Dennis G. Gillingham, «A new water soluble copper N-heterocyclic carbene complex delivers mild O6G-selective RNA alkylation», Chemical Communications 2018, 54, 9174─9177. doi:10.1039/C8CC04476G.

  • Basilius Sauter and Dennis G. Gillingham, «Profiling the nucleobase and structure selectivity of anticancer drugs and other DNA alkylating agents by RNA sequencing », ChemBioChem 2018, 19, 1638─1642. doi:10.1002/cbic.201800235.

  • Jingming Zhao, Daniel Bachmann, Markus Lenz, Dennis G. Gillingham and Thomas R. Ward, «An Artificial Metalloenzyme for Carbene Transfer Based on a Biotinylated Dirhodium Anchored within Streptavidin», Catalysis Science & Technology 2018, 8, 2294─2298. doi:10.1039/C8CY00646F.

2017

  • Dennis G. Gillingham and Basilius Sauter, «Genomic studies reveal new aspects of the biology of DNA damaging agents», ChemBioChem 2017, 18, 2368─2375. doi:10.1002/cbic.201700520.

  • Stefanie Geigle, Laura A. Wyss, Shana J. Sturla and Dennis G. Gillingham, «Copper carbenes alkylate guanine chemoselectively through a substrate directed reaction», Chemical Science 2017, 8, 499─506. doi:10.1039/c6sc03502g.

2016

  • Dennis G. Gillingham, «The role of boronic acids in accelerating condensation reactions of α-effect amines with carbonyls», Organic & Biomolecular Chemistry 2016, 14, 7606─7609. doi:10.1039/C6OB01193D.

  • Na Fei, Basilius Sauter and Dennis G. Gillingham, «The pKa of Bronsted acids controls their reactivity with diazo compounds.», Chemical Communications 2016, 52, 47, 7501─7504. doi:10.1039/c6cc03561b.

  • Cedric J. Stress, Pascal Schmidt and Dennis G. Gillingham, «Comparison of boron-assisted oxime and hydrazone formations leads to the discovery of a fluorogenic variant.», Organic & Biomolecular Chemistry 2016, 14, 24, 5529─5533. doi:10.1039/C6OB00168H.

  • Dennis G. Gillingham, Stefanie Geigle and O. Anatole Lilienfeld, «Properties and reactivity of nucleic acids relevant to epigenomics, transcriptomics, and therapeutics», Chemical Society Reviews 2016, 45, 9, 2637─2655. doi:10.1039/c5cs00271k.

2015

  • Kiril Tishinov and Dennis G. Gillingham, «Synthesis of New Alkylated Mononucleotide Analogues and Their Repair Proficiency by the Prokaryotic DNA Repair Protein AlkB», Synlett 2015, 26, 19, 2720─2723. doi:10.1055/s-0035-1560491.

  • Daniel Bachmann, Pascal Schmidt, Stefanie Geigle, Antoinette Chougnet, Wolf-Dietrich Woggon and Dennis G. Gillingham, «Modular Ligands for Dirhodium Complexes Facilitate Catalyst Customization», Advanced Synthesis & Catalysis 2015, 357, 9, 2033─2038. doi:10.1002/adsc.201500050.

  • Dennis G. Gillingham and Ramla Shahid, «Catalysts for RNA and DNA modification», Current Opinion in Chemical Biology 2015, 25, 110─114. doi:10.1016/j.cbpa.2014.12.025.

  • Pascal Schmidt, Cedric J. Stress and Dennis G. Gillingham, «Boronic acids facilitate rapid oxime condensations at neutral pH», Chemical Science 2015, 6, 6, 3329─3333. doi:10.1039/C5SC00921A.

2014

  • Pascal Schmidt, Linna Zhou, Kiril Tishinov, Kasper Zimmermann and Dennis G. Gillingham, «Dialdehydes Lead to Exceptionally Fast Bioconjugations at Neutral pH by Virtue of a Cyclic Intermediate», Angewandte Chemie International Edition 2014, 53, 41, 10928─10931. doi:10.1002/anie.201406132.

  • Na Fei, Seraina Bluemli, Benoit-Joseph Lavantie, Lorenzo D. Bizzini, Kasper Zimmermann, Urs Jenal and Dennis G. Gillingham, «Catalytic carbene transfer allows the direct customization of cyclic purine dinucleotides», Chemical Communications 2014, 50, 62, 8499─8502. doi:10.1039/C4CC01919A.

2013

  • Daniel Bachmann, Christopher C. Witter and Dennis G. Gillingham, «Stereoselective Heck Reactions with Vinyl Sulfoxides, Sulfides and Sulfones», Advanced Synthesis & Catalysis 2013, 355, 18, 3703─3707. doi:10.1002/adsc.201300678.

  • Dennis G. Gillingham and Na Fei, «Catalytic X-H insertion reactions based on carbenoids», Chemical Society Reviews 2013, 42, 12, 4918─4931. doi:10.1039/C3CS35496B.

  • Dennis G. Gillingham and Kiril Tishinov, «Synthesis of Nucleic Acid Polymers with Non-Canonical Nucleobases», Synlett 2013, 24, 8, 893─897. doi:10.1055/s-0032-1318493.

  • Kiril Tishinov, Na Fei and Dennis G. Gillingham, «Cu(I)-catalysed N-H insertion in water: a new tool for chemical biology», Chemical Science 2013, 4, 12, 4401─4406. doi:10.1039/C3SC51363G.

2012

  • Kiril Tishinov, Kristina Schmidt, Daniel Häusinger and Dennis G. Gillingham, «Structure-Selective Catalytic Alkylation of DNA and RNA», Angewandte Chemie International Edition 2012, 51, 12000─12004. doi:10.1002/anie.201205201.

  • Dennis G. Gillingham, Alexandre Martinez and Zbigniew Pianowski, «A Report from the 47th EUCHEMS Conference on Stereochemistry: The Bürgenstock Conference», Chimia 2012, 66, 873─875. doi:10.2533/chimia.2012.873.

  • Pierre Stallforth, Stefan Matthies, Alexander Adibekian, Dennis G. Gillingham, Donald Hilvert and Peter Seeberger, «A De novo chemoenzymatic synthesis of sialic acid», Chemical Communications 2012, 48, 11987─11989. doi:10.1039/c2cc37305j.

Older

  • Clemens Mayer, Dennis G. Gillingham, Thomas R. Ward and Donald Hilvert, «An artificial metalloenzyme for olefin metathesis», Chemical Communications 2011, 47, 12068─12070. doi:10.1039/C1CC15005G.

  • Dennis G. Gillingham, Pierre Stallforth, Alexander Adibekian, Peter Seeberger and Donald Hilvert, «A Chemoenzymatic Synthesis of Differentially Protected 3-Deoxysugars», Nature Chemistry 2010, 2, 102─105. doi:10.1038/nchem.504.

    • This article was also featured in the News and Views section: Benjamin G. Davis, «Enzyme catalysis: Sweet flexibility», Nature Chemistry 2010, 2, 85─86. doi:10.1038/nchem.529
  • Jörg M. Serafimov, Dennis G. Gillingham, Simon Kuster and Donald Hilvert, «The Putative Diels-Alderase Macrophomate Synthase is an Efficient Aldolase», Journal of the American Chemical Society 2008, 130, 7798─7799. doi:10.1021/ja8017994.

  • Yunmi Lee, Katsuhiro Akiyama, Dennis G. Gillingham, M. Kevin Brown and Amir H. Hoveyda, «Highly Site- and Enantioselective Cu-Catalyzed Allylic Alkylation Reactions with Easily Accessible Vinylaluminum Reagents», Journal of the American Chemical Society 2008, 130, 446─447. doi:10.1021/ja0782192.

  • Dennis G. Gillingham and Amir H. Hoveyda, «Chiral N-Heterocyclic Carbenes in Natural Product Synthesis: Application of Ru-Catalyzed Asymmetric Ring-Opening/Cross-Metathesis and Cu-Catalyzed Allylic Alkylation to Total Synthesis of Baconipyrone C», Angewandte Chemie International Edition 2007, 46, 3860─3864. doi:10.1002/anie.200700501.

  • Dennis G. Gillingham, Osamu Kataoka, Steven B. Garber and Amir H. Hoveyda, «Efficient Enantioselective Synthesis of Functionalized Tetrahydropyrans by Ru-Catalyzed Asymmetric Ring-Opening Metathesis/Cross-Metathesis (AROM/CM)», Journal of the American Chemical Society 2004, 126, 12288─12290. doi:10.1021/ja0458672.

  • Amir H. Hoveyda, Dennis G. Gillingham, Joshua J. VanVeldhuizen, Osamu Kataoka, Steven B. Garber, Jason S. Kingsbury and Joseph P. Harrity, «Ru Complexes Bearing Bidentate Carbenes: From Innocent Curiosity to Uniquely Effective Catalysts for Olefin Metathesis», Organic & Biomolecular Chemistry 2004, 2, 8─23. doi:10.1039/b311496c.

  • Joshua J. VanVeldhuizen, Dennis G. Gillingham, Stephen B. Garber, Osamu Kataoka and Amir H. Hoveyda, «Chiral Ru-based Complexes for Asymmetric Olefin Metathesis: Enhancement of Catalyst Activity through Steric and Electronic Modifications», Journal of the American Chemical Society 2003, 125, 12502─12508. doi:10.1021/ja0302228.

Contact

Fon: +41 (0)61 207 11 48

Fax: +41 (0)61 207 09 76

Department of Chemistry, University of Basel St. Johanns-Ring 19 CH-4056 Basel Switzerland