Artificial Metalloenzymes Laboratory
Endowing Organometallic Chemistry with a (Genetic) Memory
Artificial metalloenzymes result from the incorporation of an abiotic cofactor within a protein scaffold. Such hybrid catalysts combine features reminiscent of both homogeneous catalysts and enzymes.
Merging organometallic chemistry with biotechnology.
Y. Okamoto, et al. A Cell-Penetrating Artificial Metalloenzyme Regulates a Gene Switch in a Designer Mammalian Cell. Nat. Commun. 2018. 10.1038/s41467-018-04440-0
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"Catalysis is the concept which best captures the Spirit of Chemistry: the Miracle of consumption and regeneration."
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