Artificial Metalloenzymes Laboratory

Endowing Organometallic Chemistry with a (Genetic) Memory
Artificial metalloenzymes result from the incorporation of an abiotic cofactor within a protein scaffold. Such hybrid catalysts combine features reminiscent of both homogeneous catalysts and enzymes.

Research

Merging organometallic chemistry with biotechnology.

The group

Recent publications

Y. Okamoto, et al. A Cell-Penetrating Artificial Metalloenzyme Regulates a Gene Switch in a Designer Mammalian Cell. Nat. Commun. 2018. 10.1038/s41467-018-04440-0

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Lay summary

"Catalysis is the concept which best captures the Spirit of Chemistry: the Miracle of consumption and regeneration."

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