Artificial Metalloenzymes Laboratory
Endowing Organomettallic Chemistry with a (Genetic) Memory
Artificial metalloenzymes result from the incorporation of an abiotic cofactor within a protein scaffold. Such hybrid catalysts combine features reminiscent of both homogeneous catalysts and enzymes.
Merging organometallic chemistry with biotechnology.
Jeschek M et al. Directed evolution of artificial metalloenzymes for in vivo metathesis. Nature 2016 Aug 29. http://dx.doi.org/10.1038/nature19114
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"Catalysis is the concept which best captures the Spirit of Chemistry: the Miracle of consumption and regeneration."
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