Glutamate-Glycine and Histidine-Glycine Co-oligopeptides: Batch Co-oligomerization versus Pulsed Addition of N-Carboxyanhydrides

Carole Lamy, Jérôme Lemoine, Denis Bouchu, Peter Goekjian and Peter Strazewski
ChemBioChem 2008, 9, 710-713

Glutamate-Glycine and Histidine-Glycine Co-oligopeptides: Batch Co-oligomerization versus Pulsed Addition of N-Carboxyanhydrides

Synthetic random copolypeptides from aqueous solutions that contain the catalytically competent amino acid histidine remained elusive for many decades because of histidine's much slower polymerization rate compared to activated precursors of glutamate or glycine. By using a pulsed addition mode we obtained His-Gly co-oligopeptides of up to 29 residues and controllable average His-Gly ratios.