Synthesis of (–)-neplanocin A with the highest overall yield via an efficient Mitsunobu coupling
Neplanocin A was synthesized in very high isolated yields and purity, in ten steps from D-ribose via an efficient Mitsunobu coupling using N6-bis-Boc-protected adenine. In fact, this synthesis is a short pathway to enantiopure Neplanocin A giving the highest published overall yield.
