Hubert Chapuis and Peter Strazewski Tetrahedron2006, 62, 12108-12115
Shorter Puromycin Analog Synthesis by Means of an Efficient Staudinger-Vilarrasa Coupling
An efficient Staudinger-Vilarrasa coupling generates amides from azides and 1-hydroxybenzotriazole esters of amino- or hydroxy acid derivatives in very high isolated yields and purity. New puromycin analogs, mostly putative biosynthetic intermediates, were synthesised in nine steps from adenosine.
