unibaselDepartment of Chemistry

Andreas Pfaltz Laboratory

Selected publications

2014

Asymmetric Hydrogenation of α,β-Unsaturated Nitriles with Base-Activated Iridium N,P Ligand Complexes.
M.-A. Müller, A. Pfaltz, Angew. Chem. Int. Ed. 2014, 53, 8668. (abstract)

Asymmetric Hydrogenation of Maleic Acid Diesters and Anhydrides.
M. Bernasconi, M.-A. Müller, A. Pfaltz, Angew. Chem. Int. Ed. 2014, 53, 5385. (abstract)

Iridium-Catalyzed Asymmetric Hydrogenation of 3,3-Disubstituted Allylic Alcohols in Ethereal Solvents.
M. Bernasconi, V. Ramella, P. Tosatti, A. Pfaltz, Chem. Eur. J. 2014, 20, 2440. (abstract)

Asymmetric Hydrogenation with Iridium C,N and N,P Ligand Complexes: Characterization of Dihydride Intermediates with a Coordinated Alkene.
S. Gruber, A. Pfaltz, Angew. Chem. Int. Ed. 2014, 53, 1896. (abstract)

Toward force fields for atomistic simulations of iridium-containing complexes.
F. D. Hofmann, M. Devereux, A. Pfaltz, M. Meuwly, J. Comput. Chem. 2014, 35, 18. (abstract)

Synthesis of functionalized pyridinium salts bearing a free amino group.
J. Auth, P. Mauleon, A. Pfaltz, ARKIVOC 2014, 154. (abstract)

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2013

A Convergent and Stereoselective Synthesis of the Glycolipid Components Phthioceranic Acid and Hydroxyphthioceranic Acid.
M. C. Pischl, C. F. Weise, M.-A. Müller, A. Pfaltz, C. Schneider, Angew. Chem. Int. Ed. 2013, 34, 8968. (abstract)

Organocatalytic Asymmetric Conjugate Addition of Aldehydes to Nitroolefins: Identification of Catalytic Intermediates and the Stereoselectivity-Determining Step by ESI-MS.
F. Bächle, J. Duschmale, C. Ebner, A. Pfaltz, H. Wennemers, Angew. Chem. Int. Ed. 2013, 52, 12619. (abstract)

Characterization and Reactivity Studies of Dinuclear Iridium Hydride Complexes prepared from Iridium Catalysts with N,P and C,N Ligands under Hydrogenation Conditions.
S. Gruber, M. Neuburger, A. Pfaltz, Organometallics, 2013, 32, 4702-4711. (abstract)

Chiral N-Heterocyclic Carbene/Pyridine Ligands for the Iridium-Catalyzed Asymmetric Hydrogenation of Olefins.
A. Schumacher, M. Bernasconi, A. Pfaltz, Angew. Chem. Int. Ed. 2013, 52, 7422. (abstract)

Discovery of an iridacycle catalyst with improved reactivity and enantioselectivity in the hydrogenatioin of dialkyl ketimines.
Y. Schramm, F. Barrios-Landeros, A. Pfaltz, Chem. Sci. 2013, 4, 2760. (abstract)

Double-Asymmetric Hydrogenation Strategy for the Reduction of 1,1-Diaryl Olefins Applied to an Improved Synthesis of CuIPhEt, a C2-Symmetric N-Heterocyclic Carbenoid.
E. Spahn, A. Albright, M. Shevlin, L. Pauli, A. Pfaltz, R. E. Gawley, J. Org. Chem. 2013, 78, 2731. (abstract)

Asymmetric Hydrogenation Using Rhodium Complexes Generated from Mixtures of Monodentate Neutral and Anionic Phosphorus Ligands.
D. J. Frank, A. Franzke, A. Pfaltz, Chem. Eur. J. 2013, 19, 2405. (abstract)

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2012

A General, Asymmetric, and Noniterative Synthesis of Trideoxypropionates. Straightforward Syntheses of the Pheromones (+)-Vittatalactone and (+)-Norvittatalactone.
C. F. Weise, M. C. Pischel, A. Pfaltz, C. Schneider J. Org. Chem. 2012, 77, 1477. (abstract)

Chiral Proline-Based P,O and P,N Ligands for Iridium-Catalyzed Asymmetric Hydrogenation.
D. Rageot, A. Pfaltz, Helvetica Chimica Acta 2012, 95, 2176. (abstract)

Asymmetric Hydrogenation of α,β-Unsaturated Carboxylic Esters with Chiral Iridium N,P Ligand Complexes.
D. H. Woodmansee, M.-A. Müller, L. Tröndlin, E. Hörmann, A. Pfaltz, Chem. Eur. J. 2012, 18, 13780. (abstract)

Iridium-Catalyzed Enantioselective Hydrogenation of Alkenylboronic Esters
A. Ganic, A. Pfaltz, Chem. Eur. J. 2012, 18, 6724. (abstract)

Recent Advances in Iridium-Catalyzed Asymmetric Hydrogenation: New Catalysts, Substrates and Applications in Total Synthesis
A. Ganic, D. Rageot, L. Tröndlin, A. Pfaltz, Chimia 2012, 66, 187. (abstract)

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2011

A non-iterative, flexible, and highly stereoselective synthesis of polydeoxypropionates-synthesis of (+)-vittatalactone.
C. F. Weise, M. C. Pischel, A. Pfaltz, C. Schneider Chem. Commun. 2011, 47, 3248. (abstract)

Enantioselective Synthesis of cis-1,2-Disubstituted Cyclopentanes and Cyclohexanes by Suzuki–Miyaura Cross-Coupling and Iridium-Catalyzed Asymmetric Hydrogenation
A. Schumacher, M. G. Schrems, A. Pfaltz, Chem. Eur. J. 2011, 17, 13502. (abstract)

Chiral Dihydrobenzo[1,4]oxazines as Catalysts for the Asymmetric Transfer-Hydrogenation of α,β-Unsaturated Aldehydes
C. Ebner, A. Pfaltz, Tetrahedron 2011, 67, 10287. (abstract)

Proline-Based P,O Ligand/Iridium Complexes as Highly Selective Catalysts: Asymmetric Hydrogenation of Trisubstituted Alkenes.
D. Rageot, D. H. Woodmansee, B. Pugin, A. Pfaltz, Angew. Chem. 2011, 123, 9772; Angew. Chem. Int. Ed. 2011, 50, 9598. (abstract)

Catalytic Enantioselective Total Synthesis of (+)-Torrubiellone C.
H. J. Jessen, A. Schumacher, F. Schmid, A. Pfaltz, K. Gademann, Org. Lett. 2011, 13, 4368. (abstract)

Asymmetric hydrogenation of alkenes lacking coordinating groups.
D. H. Woodmansee, A. Pfaltz, Chem. Commun. 2011, 47, 7912. (abstract)

Synthesis of new serine-based phosphinooxazoline ligands and iridium complexes for asymmetric hydrogenations.
A. Franzke F. Voss, A. Pfaltz, Tetrahedron 2011, 67, 4358. (abstract)

A Unified Approach for the Stereoselective Total Synthesis of Pyridone Alkaloids and Their Neuritogenic Activity.
H. J. Jessen, A. Schumacher, T. Shaw, A. Pfaltz, K. Gademann, Angew. Chem. 2011, 123, 4308; Angew. Chem. Int. Ed. 2011, 50, 4222. (abstract)

Determining the Enantioselectivity of Chiral Catalysts by Mass Spectrometric Screening of Their Racemic Forms.
C. Ebner, C. A. Müller, C. Markert, A. Pfaltz, J. Am. Chem. Soc. 2011, 133, 4710. (abstract) (pdf)

Zwitterionic Iridium Complexes with P,N-Ligands as Catalysts for the Asymmetric Hydrogenation of Alkenes.
A. Franzke, A. Pfaltz, Chem. Eur. J. 2011, 17, 4131. (abstract)

Iridium-Catalyzed Asymmetric Hydrogenation of Unfunctionalized, Trialkyl-Substituted Olefins.
A. Wang, R. P. Fraga, E. Hörmann, A. Pfaltz, Chem. Asian J. 2011, 6, 599. (abstract)

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2010

Unprecedented Reactivity of Iridium(I) Secondary Phosphine Oxide Complexes: Formation of P-Coordinated Phosphinate Complexes by P-Aryl Bond Cleavage.
M. Liniger, B. Gschwend, M. Neuburger, S. Schaffner, A. Pfaltz, Organometallics 2010, 29, 5953. (abstract)

Chiral Mixed Secondary Phosphine-Oxide-Phosphines: High-Performing and Easily Accessible Ligands for Asymmetric Hydrogenation.
H. Landert, F. Spindler, A. Wyss, H.-U. Blaser, B. Pugin, Y. Ribourduoille, B. Gschwend, B. Ramalingam, A. Pfaltz, Angew. Chem. 2010, 122, 7025; Angew. Chem. Int. Ed. 2010, 49, 6873. (abstract)

Bis((2-methoxymethyl)pyrrolidine)phosphine as effective chiral auxiliary for the stereoselective synthesis of chiral ferrocenyl diphosphines.
M. Lotz, B. Pugin, M. Kesselgruber, M. Thommen, F. Spindler, H.-U. Blaser, A. Pfaltz, M. Schoenleber Tetrahedron: Asymmetry 2010, 21, 1199. (abstract)

An expeditious asymmetric formal synthesis of the antibiotic platensimycin.
K. Tiefenbacher, L. Tröndlin, J. Mulzer, A. Pfaltz, Tetrahedron 2010, 66, 6508. (abstract)

Chiral Pyridyl Phosphinites with Large Aryl Substituents as Efficient Ligands for the Asymmetric Iridium-Catalyzed Hydrogenation of Difficult Substrates.
D. H. Woodmansee, M.-A. Müller, M. Neuburger, A. Pfaltz, Chem. Sci. 2010, 1, 72. (abstract)

Iridium-Catalyzed Asymmetric Hydrogenation of Imines.
A. Baeza, A. Pfaltz, Chem. Eur. J. 2010, 16, 4003. (abstract)

Iridium-Catalyzed Asymmetric Hydrogenation of N-Protected Indoles.
A. Baeza, A. Pfaltz, Chem. Eur. J. 2010, 16, 2036. (abstract)

Total Synthesis and Absolute Configuration of Macrocidin A, a Cyclophane Tetramic Acid Natural Product.
T. Yoshinari, K. Ohmori, M. G. Schrems, A. Pfaltz, K. Suzuki, Angew. Chem. 2010, 122, 893; Angew. Chem. Int. Ed. 2010, 49, 881. (abstract)

Enantioselective Michael Addition to α,β-Unsaturated Aldehydes: Combinatorial Catalyst Preparation and Screening, Reaction Optimization, and Mechanistic Studies.
I. Fleischer, A. Pfaltz, Chem. Eur. J. 2010, 16, 95. (abstract)

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2009

P-Chiral Ferrocenephospholanes: Synthesis, Reactivity, Metal Complex Chemistry and Application in the Asymmetric Hydrogenation of Olefins.
B. Gschwend, B. Pugin, A. Bertogg, A. Pfaltz, Chem. Eur. J. 2009, 15, 12993. (abstract)

Iridium-Catalyzed Asymmetric Hydrogenation of Unfunctionalized Enamines.
A. Baeza, A. Pfaltz, Chem. Eur. J. 2009, 15, 2266. (abstract)

Mass Spectrometric Screening of Chiral Catalysts and Catalyst Mixtures. Feature Article.
C. A. Müller, C. Markert, A. M. Teichert, A. Pfaltz, Chem. Commun. 2009, 1607. (abstract)

(+)- and (-)-Mutisianthol: First Total Synthesis, Absolute Configuration, and Antitumor Activity.
G. G. Bianco, M. C. Ferraz, A. M. Costa, L. V. Costa-Lotufo, C. Pessoa, M. O. de Moraes, M. G. Schrems, A. Pfaltz, L. F. Silva, Jr., J. Org. Chem. 2009, 74, 2561. (abstract)

NeoPHOX – an Easily Accessible P,N Ligand for Iridium-Catalyzed Asymmetric Hydrogenation: Preparation, Scope and Application in the Synthesis of Demethyl Methoxycalamenene.
M. G. Schrems, A. Pfaltz Chem. Commun. 2009, 6210. (abstract)

Chromatography-free Enzymatic Kinetic Resolution of Secondary Alcohols.
M. Maywald, A. Pfaltz, Synthesis 2009, 21, 3654. (abstract)

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2008

Mass Spectrometric Screening of Enantioselective Diels-Alder Reactions.
A. Teichert, A. Pfaltz, Angew. Chem. 2008, 3408; Angew. Chem. Int. Ed. 2008, 47, 3360. (abstract)

Chiral Boron-Bridged Bisoxazoline (borabox) Ligands: Structure and Reactivity of Pd and Cu Complexes.
V. Köhler, C. Mazet, A. Toussaint, K. Kulicke, D. Häussinger, M. Neuburger, S. Schaffner, S. Kaiser, A. Pfaltz, Chem. Eur. J. 2008, 14, 8530. (abstract)

Chiral Bis(N-arylamino)phosphine-oxazolines: Synthesis and Application in Asymmetric Catalysis.
M. Schönleber, R. Hilgraf, A. Pfaltz, Adv. Synth. Catal. 2008, 350, 2033. (abstract)

Enantioselective Synthesis of Chromanes by Iridium-Catalyzed Asymmetric Hydrogenation of 4H-Chromenes.
C. Valla, A. Baeza, Menges, A. Pfaltz, Synlett 2008, 3167. (abstract)

Asymmetric Henry Reactions Catalyzed by Metal Complexes of Chiral Boron-Bridged Bisoxazoline (borabox) Ligands.
A. Toussaint, A. Pfaltz, Eur. J. Org. Chem., 2008, 4591. (abstract)

Phosphinomethyl-Oxazolines as Effective Ligands for the Iridium-Catalyzed Enantioselective Hydrogenation of Unfunctionalized Tetrasubstituted Olefins.
M. G. Schrems, E. Neumann, A. Pfaltz, Heterocyles, 2008, (Special issue dedicated to Prof Noyori on the occasion of his 70th birthday), 76, 771. (abstract)

Mass Spectrometric Screening of Chiral Catalysts by Monitoring the Back Reaction of Quasienantiomeric Products: Pd-Catalyzed Allylic Substitution.
C. A. Müller, A. Pfaltz, Angew. Chem., 2008, 120, 3411; Angew. Chem. Int. Ed., 2008, 47, 3363. (abstract)

Combinatorial Ligand Development Based on Mass Spectrometric Screening and a Double Mass-Labeling Strategy.
C. Markert, P. Rösel, A. Pfaltz, J. Am. Chem. Soc., 2008, 130, 3234. (abstract)

Enantio- and Diastereoselective Hydrogenation of Farnesol and O-Protected Derivatives: Stereocontrol through Adjustment of C=C Bond Configuration.
A. Wang, B. Wüstenberg, A. Pfaltz, Angew. Chem., 2008, 120, 2330; Angew. Chem. Int. Ed., 2008, 47, 2298. (abstract)

Synthesis of Functionalized Borate Building Blocks for the Anionic Derivatization of Neutral Compound.
A. Franzke, A. Pfaltz, Synthesis, 2008, 245. (abstract)

Homogeneous Hydrogenation of Tri- and Tetrasubstituted Olefins: Comparison of Ir-PHOX Complexes and Crabtree Catalysts with Hexafluorophosphate and Tetrakis[3,5-bis(trifluoro­methyl)­phenyl]borate (BArF) as Counterions.
B. Wüstenberg, A. Pfaltz, Adv. Synth. Catal., 2008, 350, 174. (abstract)

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2007

Kinetic Resolution of Pyridyl Alcohols by Cu(II)(Borabox)-Catalyzed Acylation.
S. Roseblade, A. Pfaltz, Synthesis, 2007, 3751. (abstract)

Iridium-Catalyzed Asymmetric Hydrogenation of Olefins.
S. J. Roseblade, A. Pfaltz, Acc. Chem. Res., 2007, 40, 1402. (abstract)

Iridium–Catalyzed Asymmetric Hydrogenation of Unfunctionalized Tetrasubstituted Olefins.
M. G. Schrems, E. Neumann, A. Pfaltz, Angew. Chem., 2007, 119, 8422; Angew. Chem. Int. Ed., 2007, 46, 8274. (abstract)

Synthesis and Metal Complexes of Chiral C2-Symmetric Diamino-Bisoxazoline Ligands.
G. Guillemot, M. Neuburger, A. Pfaltz, Chem. Eur. J., 2007, 13, 8960. (abstract)

Asymmetric Catalytic Intramolecular Pauson-Khand Reactions with Iridium-PHOX Catalysts.
Z.-L. Lu, E. Neumann, A. Pfaltz, Angewandte Chemie, International Edition, 2007, 46(31), 5892-5895. (abstract)

Palladium-catalyzed allylic substitution: reversible formation of allyl-bridged dinuclear palladium(I) complexes
Christian Markert, Markus Neuburger, Klaus Kulicke, Markus Meuwly, Andreas Pfaltz, Eur. J. Org. Chem., 2007, 4189. (abstract)

Synthesis of Chiral C2-Symmetric Methylene- and Boron-Bridged Bis(imidazoline) Ligands.
B. Ramalingam, M. Neuburger, A. Pfaltz, Synthesis, 2007, 46(31), 572. (abstract)

Recent Advances in Iridium Catalysed Asymmetric Hydrogenation of Unfunctionalised Olefins
S. J. Roseblade, A. Pfaltz, Comptes Rendus Chimie, 2007, 10, 178-187. (abstract)

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2006

Comprehensive Kinetic Screening of Palladium Catalysts for Heck Reactions
D. G. Blackmond, T. Schultz, J. S. Mathew, C. Loew, T. Rosner, A. Pfaltz, Synlett 2006, 18, 3135-3140. (abstract)

Chiral Phosphino- and (Phosphinooxy)-Substituted N-Heterocyclic Carbene Ligands and Their Application in Iridium-Catalyzed Asymmetric Hydrogenation
S. Nanchen, A. Pfaltz, Helv. Chim. Acta 2006, 89, 1559-1573. (abstract)

Iridium Catalysts with Bicyclic Pyridine-Phosphinite Ligands: Asymmetric Hydrogenation of Olefins and Furan Derivatives
S. Kaiser, S. P. Smidt, A. Pfaltz, Angew. Chem. Int. Ed. 2006, 45, 5194-5197. (abstract)

Enantioselective Routes to (-)-(R)-Muscone
B. Bulic, U. Lücking, A. Pfaltz, Synlett 2006, 7, 1031-1034. (abstract)

Synthesis and Application of Chiral N-Heterocyclic Carbene-Oxazoline Ligands:
Iridium-Catalyzed Enantioselective Hydrogenation
S. Nanchen, A. Pfaltz, Chem. Eur. J. 2006, 12, 4550-4558. (abstract)

Kinetic Resolution of Diols and Pyridyl Alcohols by Cu(II)(borabox)-Catalyzed Acylation
C. Mazet, S. Roseblade, V. Köhler, A. Pfaltz, Org. Lett. 2006, 8, 1879-1882. (abstract)

Asymmetric Hydrogenation of Unfunctionalized, purely Alkyl-substituted Olefins
S. Bell, B. Wüstenberg, S. Kaiser, F. Menges, T. Netscher, A. Pfaltz, Science 2006, 311(5761), 642-644. (abstract)

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2005

Chiral boron-bridged bisoxazolines: Readily available anionic ligands for asymmetric catalysis.
C. Mazet, V. Kohler, A. Pfaltz, Angew. Chem. Int. Ed. 2005, 44, 4888-4891. (abstract)

Enantio- and diastereoselective [3+2] cycloadditions of azomethine ylides with Ag(I)-phosphinooxazoline catalysts.
R. Stohler, F. Wahl, A. Pfaltz, Synthesis 2005, 9, 1431-1436. (abstract)

Immobilization of Rhodium Complexes at Thiolate Monolayers on Gold Surfaces: Catalytic and Structural Studies.
T. Belser, M. Stoehr, A. Pfaltz, J. Am. Chem. Soc. 2005, 127, 8720-8731. (abstract)

Palladium(II) complexes with chelating P,O-ligands as catalysts for the Heck reaction.
T. Schultz, A. Pfaltz, Synthesis 2005, 6, 1005-1011. (abstract)

Iridium-catalyzed enantioselective hydrogenation of terminal alkenes.
S. McIntyre, E. Hoermann, F. Menges, S. P. Smidt, A. Pfaltz, Adv. Synth. Catal. 2005, 347, 282-288. (abstract)

Synthesis and Characterization of Cationic Rhodium Complexes with Stable Silylenes.
E. Neumann, A. Pfaltz, Organometallics 2005, 24, 2008-2011. (abstract)

Chiral bis(N-sulfonylamino)phosphine- and TADDOL-phosphite-oxazoline ligands: synthesis and application in asymmetric catalysis.
R. Hilgraf, A. Pfaltz, Adv. Synth. Catal. 2005, 347, 61-77. (abstract)

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