Recent Publications

 

Radical Reactions in Biological Systems
 

Electron Transfer through DNA and Peptides:

M. Lauz, S. Eckhardt, K. M. Fromm, B. Giese

The influence of dipole moments on the mechanism of electron transfer through helical peptides

PhysChemChemPhys. 2012, ASAP.


B. Giese, S. Eckhardt, M. Lauz, J. Gao, M. Wang

Radicals and Radical Ions as Intermediates of Electron Transfer Processes through Peptides

CHIMIA 2012, 66, no. 6.


A. Heck, P. B. Woiczikowski, T. Kubar, B. Giese, M. Elstner, T. B. Steinbrecher

Charge Transfer in Model Peptides: Obtaining Marcus Parameters from Molecular Simulation

J. Phys. Chem. 2012, 116, 2284.


B. Giese, S. Eckhardt, M. Lauz

Electron Transfer in Peptides and Proteins

Encyclopedia of Radicals (C. Chatgilialogly, A. Studer, Eds.) Wiley, 2012, 1473.


J. Gao, S. Eckhardt, M. Lauz, P. Müller, M. Wang, K. M. Fromm, B. Giese

Electron Transfer in Peptides: The Influence of Charged Amino Acids

Angew. Chem. 2011, 50, 1926.


M. Wang, J. Gao, P. Müller, B. Giese

Electron Transfer in Peptides with Cysteine and Methionine as Relay Amino Acids

Angew. Chem. 2009, 48, 4232.


B. Giese, M. Wang, J. Gao, M. Stolz, P. Müller, M. Graber

Electron Relay in Peptides

J. Org. Chem. 2009, 74, 3621.


M. Cordes and B. Giese

Electron Transfer in Peptides

Chem. Soc. Review 2009, 38, 892.


Bernd Giese, Michael Graber, Meike Cordes
Electron transfer in peptides and proteins
Cur. Opin. Chem. Biol. 2008, 12, 755.


Meike Cordes, Olivier Jaques, Agnieszka Köttgen, Christian Jasper, Hassen Boudebous, Bernd Giese
Development of a Model System for Long Distance Electron Transfer in Peptides
Adv.
Synth. Catal. 2008, 350, 1053.


Meike Cordes, Agnieszka Köttgen, Christian Jasper, Olivier Jaques, Hassen Boudebous, Bernd Giese
Influence of Amino Acid Side Chains on Long Distance Electron Transfer in Peptides: Electron Hopping via Stepping Stones
Angew.
Chem. 2008, 47, 3461.


Bernd Giese
Electron transfer through DNA and peptides
Bioorg.
Med. Chem. 2006, 14, 6139.


B. Giese, M. Napp, O. Jacques, H. Bodebous, A.M. Taylor, J. Wirz
Multistep Electron Transfer in Oligopeptides: Direct Observation of Radical Cation Intermediates
Angew.
Chem. Int. Ed. 2005, 44, 4073.


B. Giese, B. Carl, T. Carl, T. Carell, C. Behrens, U. Hennecke, O. Schiemann, E. Feresin
Excess Electron Transport through DNA: A Single Electron Repairs more than One UV-Included Lesion
Angew.
Chem. Int. Ed. 2004, 43, 715.


B. Giese
Hole Injection and Hole Transfer through DNA: The Hopping Mechanism
Topics Curr.
Chem. 2004, 236, 27.


B. Giese
Electron transfer in DNA
Curr.
Opin. Chem. Biol. 2002, 6, 612.


T. Kendrick, B. Giese
Charge transfer through DNA triggered by site selective charge injection into adenine
Chem.
Commun. 2002, 2016.


B. Giese, A. Biland
Recent Developments of Charge Injection and Charge Transfer in DNA
Chem.
Commun. 2002, 667.


B. Giese
Long Distance Electron Transfer through DNA
Ann.
Rev. Biochem. 2002 , 71, 51.


B. Giese, J. Amaudrut, A.-K. Köhler, M. Spormann, S. Wessely
Direct observation of hole transfer through DNA by hopping between adenine bases and by tunnelling
Nature 2001, 412, 318.


 

Signal Transduction and Enzyme Inhibition

V. Cmiljanovic, N. Cmiljanovic, B. Giese, M. Wymann
Piperazinotriazines as PI3K Inhibitors for Use in Treatment Antiproliferative Disorders
Patent No. WO/2011/135520, date 27.4.2011


V. Cmiljanovic, N. Cmiljanovic, B. Giese, M. Wymann
Spirocyclic Compound and their Use as Therapeutic Agents and Diagnostic Probes
Patent No. WO/2011/114275, date 22.9.2011


V. Cmilnovic, N. Cmjailjanovic, B. Giese, M. Wymann

Triazine, Pyrimidine and Pyridine Analogs and Their use as Therapeutic Agents and Diagnostic Probes

Patent No. WO/2010/052569, date: 14.5.2010


R. Marone, D. Erhart, A. C. Mertz, T. Bohnacker, C. Schnell, V. Cmiljanovic, F. Stauffer, C. Garcia.Echeverria, B. Giese, S-L. Maria, M. P. Wymann

Targeting Melanoma with Dual Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Inhibitors

Mol. Cancer Res. 2009, 7, 601.


A. Duerig, S. Abel, M. Folcher, M. Nicollier, T. Schwede, N. Amiot, B. Giese, U. Jenal
Second messenger-mediated spatiotemporal control of protein degradation regulates bacterial cell cycle progression
Genes Dev. 2009, 23, 93.


R. Marone V. Cmiljanovic, B. Giese, M. P. Wymann
Targeting Phosphoinositide 3-kinase - Moving Towards Therapy
Biochim.
Biophys. Acta. 2008, 159.


N. Amiot, K. Heintz, B. Giese
New Approach for the Synthesis of c-di-GMP and its Analogs
Synthesis.
2006, 4230.


T. Buterin, C. Meyer, B. Giese, H. Naegeli
DNA Quality Control by Conformational Readout on the Undamaged Strand of the Double Helix
Chem.
Biol.  2005, 12, 913.


C. Chan, R. Paul, D. Samoray, N.C. Amiot, B. Giese, U. Jenal, T. Schirmer
Structural Basis of Activity and Allosteric Control of Diguanylate Cyclase
Proc.
Natl. Acad. Sc. USA, 2004, 101, 17064.


R. Paul, S. Weiser, N.C. Amiot, C. Schan, T. Schirmer, B. Giese, W. Jenal
Cell Cycle-Dependent Dynamic Localization of a Bacterial Response Regulator with a Novel Di-Guanylate Cyclase Output Domain
Genes & Development 2004, 18, 715.


 


Last update June 13th, 2012