Fidaxomicin constitutes a newly introduced antibiotic against Clostridium difficile infections. Our group recently completed the synthesis of the fidaxomicin aglycon. This accomplishment allows for the preparation of analogues with improved properties and to understand its mechanism of action.Read the paper
Progress in the chemical sciences has formed the world we live in, both on a macroscopic and on a nanoscopic scale. The last century witnessed the development of high performance materials that interact with humans on many layers, from clothing to construction, from media to medical devices. On a molecular level, natural products and their derivatives influence many biological processes, and these compounds have enormously contributed to the health and quality of living of humans.
However, natural product approaches to designer materials, that is, combining the best of both worlds, remain scarce.
Over the last decade, we have developed a research program directed to the generation of natural product functionalized materials, exploiting the strategy of “copy, edit, and paste with natural products”.Read more in our account!